NEUROLOGIA E NEUROCHIRURGIA
Dott. Matteo De Simone
Direttore unità Neurochirurgia Brain Lab
Ricercatore in Neurochirurgia AOU Ruggi, Salerno
Su di me
MATTEO DE SIMONE, MD
Via Marcello, Mercato S. Severino SA | dr.mdesimone@gmail.com
Via S.Allende, Baronissi SA | Department “Scuola Medica Salernitana”
Affiliation | University of Salerno, Italy – B r a i n L a b
CURRENT ASSIGNMENT (05-2024 – ongoing)
- CEO of Brain Lab | Salerno, Italy
Chair of the Neurosurgical and Neuroanatomy Lab
An innovative, government grant-funded, start-up operating in scientific research in
neuroscience, neurology, and neurosurgery, creating personalized solutions and innovating
current care settings - Neurosurgery Fellow | University of Salerno
Scientific research, surgical and teaching activities at the chair of neurosurgery at the
University of Salerno, Italy. - Section Editor in Chief of Neuroanatomy | Journal of Neurosurgery (Q1 IF 3,5)
Editor Journal of Clinical Medicine | Neurosurgery: Recent Advances and New
Perspectives in Skull Base Approaches (Q1 IF 3)
https://www.mdpi.com/journal/jcm/special_issues/HZKW4XK063
EDUCATION
- Neurosurgery Fellow
Università degli Studi di Salerno | AOU San Giovanni di Dio e Ruggi - Medicine and Surgery | (LM-41)
Università degli studi di Salerno | 110 cum Laude and Special Mention
Dipartimento di Medicina e Chirurgia “Scuola Medica Salernitana” | UNISA - Scientific high school diploma with honors (100/100) | EQF-4
Liceo “Publio Virgilio Marone” | Mercato S. Severino - Cambridge English language assessment | Level C1
Centro Linguistico di Ateneo | UNISA
INTERNATIONAL TRAINING |
CLINIC, RESEARCH AND INNOVATION
1. New York Presbyterian Hospital, Weill Cornell Medical College | New York
Neuroscience Department | tutor: Dr. Schiff Fellowship program | July 2022
2. Mayo Clinic | Rochester, Minnesota
Neurosurgery Department observship | tutor: Prof. Giuseppe Lanzino | December
2022
3. Richi Childhood Cancer Foundation | Boston
Scholarship Entrepreneur program | tutor: Prof. Roberto Parente | November 2023
4. Brigham and Women’s Hospital, Harvard Medical School | Boston
Scholarship skull base | tutor: Prof. Antonio Chiocca | December 2023
5. Hospital Universitari Mutua Terrassa | Barcelona
Clinical Fellowship in Spine Surgery | tutor: dr. Edgar Casajuana | November to
December 2024
TEACHING DIPMED | UNISA
Università degli studi di Salerno | UNISA
Dipartimento di Scienze Umane, Filosofiche e della Formazione” | DISUFF
Human Anatomy Tutor (150 ore) | AA 2021/2022 to AA 2023/2024 | Referent Teacher
Prof. Angela Lucariello
Università degli studi di Salerno | UNISA
Dipartimento di Medicina Chirurgia e Odontoiatria “Scuola Medica Salernitana” | DIPMED
Academic Tutor (70 ore) | AA 2023/2024 | Docente Referente Prof. Paolo Remondelli
Università degli studi di Salerno | UNISA
Dipartimento di Medicina Chirurgia e Odontoiatria “Scuola Medica Salernitana” | DIPMED
Tutor Tolc Med (10 ore) | AA 2022/2023 | Docente Referente Prof. Giulia Savarese
Università degli studi di Salerno | UNISA
Dipartimento di Medicina Chirurgia e Odontoiatria “Scuola Medica Salernitana” | DIPMED
Academic Tutor (100 ore) | AA 2022/2023 | Docente Referente Prof. Paolo Remondelli
Università degli studi di Salerno | UNISA
Dipartimento di Medicina Chirurgia e Odontoiatria “Scuola Medica Salernitana” | DIPMED
Prof a.c. in Neurochirurgia (100 ore) | AA 2023/2024
GRANTs
Grant A.L.I. by SeiUNISA (bando FOND/86 del 04/12/2023)
Market Validation and technology development of BrainLab (innovative start-up)
https://www.fondazione.unisa.it/uploads/4883/pubblicazione_graduatoria_finale_di_merito_bando_ali.pdf
Grant A.L.I. fase seed by SeiUNISA (FOND/50 del 20/12/2024)
Funding on a project with funds from the University of Salerno to finance research on spinal
and
cranial neurosurgical pathology
https://www.fondazione.unisa.it/uploads/4883/pubblicazione_elenco_ammessi_e_non_ammessi_a_contribuzione.pdf
INNOVATION AND TECHNOLOGY TRANSFER
WINNER of public selection by titles and interviews for the awarding of scholarships to
deserving students for participation in training activities and animation of the student
community on the topics of Innovation and Entrepreneurship under the UNISA STUDENT
ENTREPRENEURSHIP & INNOVATION project (FOND/14 of 03/03/2023)
Founded PROJECTS
WINNER public selection “Innovation Community” for the purpose of awarding scholarships
to students, graduates or PhD students developing business projects under the UNISA
STUDENT ENTREPRENEURSHIP & INNOVATION (SEIUNISA) project (FOND/53 of
17/06/2023)
Project on cancer and cardiocerebrovascular prevention called “oCare”
DIRECTION OR PARTICIPATION IN THE ACTIVITIES OF A RESEARCH GROUP
CHARACTERIZED BY NATIONAL OR INTERNATIONAL COLLABORATIONS
Funding FARB | 2023
BRAINTRIM – BRAIN RESEARCH AND INNOVATION IN TRAUMATIC INJURY THROUGH
MIRNA
(Cod. ORSA237218) PI: Prof. A.Santurro
Funding FARB | 2024
Immunophenotypic characterization of cellular infiltrate in chronic subdural hematoma: a
pilot study on new pathophysiological and translational aspects.
(Cod. ORSA249994) PI: Dr.E.Ciaglia
SYNOPSIS SCHOLARSHIPS AND ASSIGNMENTS |
- Borsa di studio Innovator | Fondazione UNISA (100 ore)
Febbraio 2023 ~ Dicembre 2023
- Incarico di collaborazione part-time | DIPMED UNISA (150 ore)
Dicembre 2022 ~ Dicembre 2023 - Incarico di Tutor Accademico con il Dipartimento | DIPMED UNISA (70 ore)
Novembre 2022 ~ Giugno 2023 - Incarico di Commissario d’aula Tolc 2023 | DIPMED UNISA (10 ore)
Aprile 2023 ~ Luglio 2023 - Incarico di Tutor Accademico con il Dipartimento | DIPMED UNISA (100 ore)
Settembre 2023 ~ Gennaio 2024
PUBLICATIONS, ABSTRACTS AND CONGRESSES
PUBLICATIONS
1. Conti, V.; Corbi, G.; ..De Simone, M.;..Rosa, N.; Pagliano, P.; Filippelli, A. Long
COVID: Clinical Framing, Biomarkers, and Therapeutic Approaches. J. Pers. Med.
2023, 13, 334.
https://doi.org/10.3390/jpm13020334 (IF 3,4)
2. De Simone M., Conti V, Palermo G, De Maria L, Iaconetta G. Advancements in
Glioma Care: Focus on Emerging Neurosurgical Techniques. Biomedicines. 2024;
12(1):8. https://doi.org/10.3390/biomedicines12010008 (Q1, IF 4,7) Corresponding:
Matteo De Simone
3. De Simone, M.; De Feo, R.; Choucha, A.; Ciaglia, E.; Fezeu, F. Enhancing Sleep
Quality: Assessing the Efficacy of a Fixed Combination of Linden, Hawthorn, Vitamin
B1, and Melatonin. Med. Sci. 2024, 12, 2. https://doi.org/10.3390/medsci12010002
Corresponding: Matteo De Simone
4. De Simone, M.; Iaconetta, G.; Palermo, G.; Fiorindi, A.; Schaller, K.; De Maria, L.
Clustering Functional Magnetic Resonance Imaging Time Series in Glioblastoma
Characterization: A Review of the Evolution, Applications, and Potentials. Brain
Sci. 2024, 14, 296. https://doi.org/10.3390/brainsci14030296 (IF 3,3)
Corresponding: Matteo De Simone
5. De Simone, M.; Fontanella, M.M.; Choucha, A.; Schaller, K.; Machi, P.; Lanzino, G.;
Bijlenga, P.; Kurz, F.T.; Lövblad, K.-O.; De Maria, L. Current and Future Applications
of Arterial Spin Labeling MRI in Cerebral Arteriovenous
Malformations. Biomedicines 2024, 12, 753.
https://doi.org/10.3390/biomedicines12040753 (Q1, IF 4,7) Corresponding: Matteo
De Simone
6. De Simone, M., Zoia, C., Choucha, A., Kong, D. S., & De Maria, L. (2024). The
Transorbital Approach: A Comprehensive Review of Targets, Surgical Techniques,
and Multiportal Variants. Journal of clinical medicine, 13(9), 2712.
https://doi.org/10.3390/jcm13092712 (Q1 IF 3,9) Corresponding: Matteo De
Simone
7. Francis Fezeu, Omar F. Jbara, Ahda Jbarah, Anis Choucha, Lucio De Maria, Elena
Ciaglia, Matteo De Simone and Samuel Samnick, PET imaging for a very early
Detection of Rapid Eye Movement Sleep Behaviour Disorder and Parkinson’s
Disease – A Model-Based Cost-Effectiveness Analysis, Clinical Neurology and
Neurosurgery, (2024) doi: https://doi.org/10.1016/j.clineuro.2024.108404 (IF 2,0)
Corresponding: Matteo De Simone
8. De Simone, M.; Choucha, A.; Dannhoff, G.; Kong, D.-S.; Zoia, C.; Iaconetta, G.
Treating Trigeminal Schwannoma through a Transorbital Approach: A Systematic
Review. J. Clin. Med. 2024, 13, 3701. https://doi.org/10.3390/jcm13133701
Corresponding: Matteo De Simone (Q1, IF 3,0)
9. Scrofani, R.; De Simone, M.; Migliorini, F.; Amoroso, E.; Maffulli, N.; Narciso, N.;
Iaconetta, G. Spontaneous Resolution of Symptomatic Synovial Cysts of the Lumbar
Spine: A Comprehensive Review with Two Illustrative Cases. Medicina 2024, 60,
1115. https://doi.org/10.3390/medicina60071115 Corresponding: Matteo De
Simone
10.Consalvo, F.; De Simone, M.; Scarpa, A.; Acerra, A.; Salzano, F.A.; Fineschi, V.;
Santurro, A. Challenges and Complications in the Management of Advanced
Oropharyngeal Carcinoma: Role of Post-Mortem Diagnosis and Future
Perspectives. J. Clin. Med. 2024, 13, 5198. https://doi.org/10.3390/jcm13175198
Corresponding: Matteo De Simone (Q1, IF 3,0)
11.De Simone, M.; Choucha, A.; Ciaglia, E.; Conti, V.; Pecoraro, G.; Santurro, A.; Puca,
A.A.; Cascella, M.; Iaconetta, G. Discogenic Low Back Pain: Anatomic and
Pathophysiologic Characterization, Clinical Evaluation, Biomarkers, AI, and
Treatment Options. J. Clin. Med. 2024, 13, 5915.
https://doi.org/10.3390/jcm13195915 Corresponding Matteo De Simone (Q1, IF
3,0)
12.Choucha, A., Troude, L., Morin, L., Fernandes, S., Baucher, G., De Simone, M., Lihi,
A., Mazen, K., Alseirihi, M., Passeri, T., Gay, E., Fournier, H. D., Jacquesson, T.,
Jouanneau, E., Froelich, S., & Roche, P. H. (2024). Management of large Trigeminal
Schwannoma: long-term oncologic and functional outcome from a multicentric
retrospective cohort. Acta neurochirurgica, 166(1), 440.
https://doi.org/10.1007/s00701-024-06292-8
13.Choucha, A., Travaglini, F., De Simone, M., Evin, M., Farah, K., & Fuentes, S. (2024).
The Da Vinci Robot, a Promising Yet Underused Minimally Invasive Tool for Spine
Surgery: a Scoping Review of its Current Role and Limits. Neuro-Chirurgie, 101624.
Advance online publication. https://doi.org/10.1016/j.neuchi.2024.101624
14.De Simone, M., Amoroso, E., & Iaconetta, G. (2025). Letter to the Editor Regarding
Does Bone Preservation at the Anterior Edge of the Vertebral Body Affect the
Subsidence of Zero-Profile Cages After Anterior Cervical Discectomy and Fusion?.
World neurosurgery, 123665. Advance online publication.
https://doi.org/10.1016/j.wneu.2025.123665 Corresponding: Matteo De Simone
(Q1, IF 3,0)
ABSTRACT
“Palatine Tonsillar hypertrophy in extra-esophageal GERD: a case report.” –
De Simone M et al.
VIII Convegno Nazionale ORL Campania 2021 | Salerno
“Combined Mechanical Asphyxia by Strangulation and Immobilization of the Chest in a case
of Matricide”
Consalvo F, De Simone M, et al.
AAFS 2024 | DENVER – USA
“Usage de l’intelligence artificielle dans la chirurgie du rachis: une étude de portée”
Anis CHOUCHA, Morgane EVIN, DE SIMONE M., H. DUFOUR, Pierre-Jean ARNOUX, K.
FARAH, S. FUENTES
SFNC 2024 | Palais du Pharo – Marseille | 27-29 March 2024
“Challenges and Solutions for Artificial Intelligence in Neurological Surgery in Low and
Middle Income Countries”
DE SIMONE M. et al.
EANS24, the Annual European Congress of Neurosurgery | National Palace of Culture,
Sofia, Bulgaria (13-17 Oct2024)
“Arterial Spin Labeling (ASL) MRI in Cerebral Arteriovenous Malformations (AVMs)”
DE SIMONE M. et al.
EANS24, the Annual European Congress of Neurosurgery | National Palace of Culture,
Sofia, Bulgaria (13-17 Oct2024)
CONGRESS
Participation by invitation to numerous conferences during his years as a university student.
As a speaker;
- VIII Convegno Nazionale ORL Campania | Grand Hotel Salerno (1-4 Dic2021)
Presentazione Poster dal titolo “Palatine Tonsillar hypertrophy in extra-esophageal
GERD: a case report.” -De Simone M et al. - Convegno Melanoma Cutaneo | DIPMED UNISA (19Gen2022)
Relazione sul melanoma cutaneo dal titolo “Overview: patogenesi clinica e
stadiazione”. - EANS24, the Annual European Congress of Neurosurgery | National Palace of
Culture, Sofia, Bulgaria (13-17 Oct2024)
Scientific Contributions with the following titles: 1) “Challenges and Solutions for
Artificial Intelligence in Neurological Surgery in Low and Middle Income Countries”
and 2) “Arterial Spin Labeling (ASL) MRI in Cerebral Arteriovenous Malformations
(AVMs)”.
As a learner:
- “Medicina di genere workshop.1, le basi” | Hotel Lloyd’s Baia– Via Benedetto Croce,
Salerno (3Oct2019) - “Seminari di Emostasi e Trombosi” | Holiday Inn – Cava de’ Tirreni (9Oct2021)
- “La Vaccinazione per l’Adulto: questa sconosciuta” | Ordine dei Medici di Salerno(12Nov2021)
- “CON CURA Gruppo di miglioramento della gestione del paziente con malattia psoriasica” | Holiday Inn | Cava de’ Tirreni (16Oct2021)
- “Il Nuovo Volto della dermatologia 4.0” | Napoli – Centro Congressi Federico II (7April2022)
- “Il MMG, l’Ospedale ed il Territorio quali prospettive per una migliore integrazione” | 7° Congresso Regionale Campania SISMED | Grand Hotel Salerno (29/30 Apr 2022)
- Transorbital Masterclass | Fondazione Ebris – Salerno (15/16 Sep 2022)
- Congresso Nazionale SiNch | Hotel Royal Continental – Napoli (13-15 Oct 2022)
- Corso di dissezione “Anatomia e Chirurgia dell’angolo ponto-cerebellare: dal laboratorio alla sala operatoria” Primo step Tour Anatomico 2023 | Fondazione Ebris, Salerno (28 Febbraio 2023) (Responsabili proff. Giorgio Iaconetta e Matteo de Notaris)
- Transorbital Masterclass | Fondazione Ebris – Salerno (15/16 Sep 2023)
- EANS 2023 | Palau de Congressos – Barcelona (24 to 28 Sep 2023)
- “XVIII corso di neuroradiologia interventistica” | Hotel Lloyd’s Baia, Salerno (19-20 Apr 2024)
- “5 th International Woekshop Endoscopic Transorbital Skull Base Surgery” | Salerno, Italy (7-9 Oct. 2024)
- Corso di dissezione “Approcci Transcranici Anterolaterali: Approcci Tradizionali Vs Mini-Invasivi” Primo step Tour Anatomico 2024 | Fondazione Ebris – Salerno (6 Giugno 2024) (Responsabili proff. Giorgio Iaconetta e Matteo de Notaris)
- Corso di dissezione “Endoscopic Endonasal Skull Base Anatomy Course” Secondo step Tour Anatomico 2024 | Istituto di Anatomia, Bologna (9-10 Dicembre 2024) (Responsabili proff. Diego Mazzatenta e Matteo Zoli)
INSTITUTIONAL ACTIVITIES
Social and political activities
Councilor elected of the Youth Forum of Mercato San Severino | biennium 2018-2020
Delegate of the Assembly of the Youth Forum Coordination of the Province of Salerno |
biennium 2018-2020
Chairman of the polling station | Decrees of Appointment of the President of the Court of
Appeal of Salerno
Regional Elections | 20 and 21 September 2020
Administrative (Municipal) Elections and Referendums | 12 and 13 June 2022
Political Elections | 25 September 2022
European Elections | 8-9 June 2024
Opportunities for the right to education | UNISA
Winner of the selection based on the average exams and credits obtained for the
assignment of part-time collaborations of students | AY 2021/2022
I place | DIPMED departmental ranking list (DR 1361/2022)
Mercato S. Severino, 01/2025
Matteo De Simone
Digitally signed pursuant to Legislative Decree 82/2005 as amended and related regulations.
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Patologie trattate
Ernia del disco lombare e cervicale
Stenosi del tratto lombare e cervicale
Neuropatie periferiche, Tunnel Carpale
Tumori del sistema nervoso centrale
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